The Neuroscience Behind NuCalm is Both Remarkable and Complex.
Our company devoted more than 19 years inventing and developing the world’s most powerful neuroscience platform to manage brain wave function safely and predictably. We call it NuCalm.
Many leading scientists believe that all of creation in this dimension is oscillatory. Mankind has become desynchronized from the master oscillatory matrix. The greater the desynchronization the greater the alienation and sense of isolation. We bring, with NuCalm, to the world, a technology that can resynchronize and restore the lost complexity. NuCalm produces coherence in the heart, which is the true seat of intelligence. When the heart and brain connection is coherent even dormant DNA potentials are released.
In the invention process we focused on 4 critical areas of the brain: the reticular activating system, the corpus callosum, the HPA axis, and the autonomic nervous system. To create effective neurobiofeedback within the complexities of the brain, we leveraged the auditory motor cortex, not just as a gateway for collecting auditory signals, but for its function in stimulating the prefrontal and frontal motor cortex. The brain is nonlinear, thus using proprietary, complex methods to present patterns that the brain won’t easily get bored with represents a significant challenge. The binaural signal processing, frequency-following-response neurobiofeedback is foundational to the software but cannot be the only effective elements. We also used specific techniques to evoke potential on a cellular level and increase electrical output focused on certain brain regions.
We spent the past 14 years testing, clinically proving, refining, and simplifying complex neuroscience to produce an easy-to-use, safe, effective, and reliable platform that brings quick relief to people. For the many who have been part of the NuCalm family for years, they have observed our continuous innovation, from NuCalm 1.0 in 2009, to NuCalm 2.0 in 2016, and now NuCalm 3.0 since November 2021. Today, with NuCalm 3.0, we provide users, for the first time ever, the capability to change their mental state on demand: without drugs, without side effects, and without compromise.
NuCalm uses complex patented physics and algorithms built inside neuroacoustic software that lies underneath music. The software presents signals to the brain that pace brain wave frequencies higher or lower. To illustrate the complexity of the neuroacoustic software, let’s say a typical song is 5MB in size. One NuCalm neuroacoustic software journey is over 1,536 MB: that’s 307 times the size of a song. The complex method used to produce the neuroacoustic software is the ONLY patented method in the world, validated by over 5 years of research throughout the patent process showcasing that nothing like this has ever existed before, and the strength and efficacy of the outcomes are irrefutable. On August 17, 2021, NuCalm was awarded a patent for “methods and devices for applying dynamic, non-linear oscillations and vibrations” to elicit a physiological state change in a human being; U.S. Patent Registration No.: 11,090,459. This patent proved that NuCalm continues to stand alone as a true pioneer with the only technology that can do what we do – change your mental state on demand simply by listening to our neuroacoustic software.
NuCalm is safe, portable, and easy-to-use. It takes seconds to self-administer and within three minutes, you will experience parasympathetic nervous system dominance that results in homeostasis of your autonomic nervous system in one treatment. Rescue, PowerNap, and FlowState expedite recovery by oscillating your brain waves in the ‘healing zone’ of theta brain wave dominance, including the hypnagogic, dissociative state of cellular restoration. This results in a synchronization of the heart and lungs and lower respiration rates to one breath every 10 seconds. This synchronicity maximizes oxygenation throughout the brain and body which removes lactic acid, lowers inflammation, and increases focus through oxygen-rich red blood cells in the frontal cortex and prefrontal cortex. In as little as 20 minutes of Rescue, PowerNap, or FlowState, you will feel focused, energized, and able to perform at a high level without emotional distraction, fear, stress, or anxiety.
“Developing a beneficial meditation practice can take countless hours over a period of years. By using NuCalm I can effectively and quickly access a state of mind where I have the ability to respond instead of react. I use NuCalm because I have post-traumatic stress. With as little as 20 minutes a day I get to respond to my feelings and thoughts instead of react to them. When I have the ability to respond I can be humble, thoughtful, patient and kind. When I react instead of respond I can be aggressive, irritable and fearful. NuCalm aids me into being the version of myself that is genuine and real. It is who I am without PTS.”
– Magnus Johnson, former Special Forces Combat Veteran“I use NuCalm every day and I have been for over 5 years. In fact, I feel like I’m at a disadvantage if I don’t use it. I call it my secret weapon and I’ve noticed with NuCalm in my life – I sleep better. I have less stress. I certainly have greater focus. And my focus has always been strong, but it’s definitely stronger. I have more mental alertness, greater levels of mental energy, and less brain fog. I have a deep sense of calm and peace. For me, peace of mind is high currency.”
– Jim Kwik, Renowned brain coach, podcaster, author, and entrepreneur“The ability of NuCalm to reduce sympathetic discharge, and its impact on the autonomic nervous system, is clearly a freestanding and noteworthy contribution to society and our high-paced, stress-filled lives. We know that every organ system in the human body is disturbed when sympathetic tone predominates excessively and chronically. The sympathetic discharge associated with sleep deprivation and long working hours under stress allows opportunistic viruses and bacteria to colonize and challenge our system. When confronted with chronic inflammatory conditions, cancer, bacterial/viral infections, and other assaults to homeostasis, it becomes critical to optimize the immune system. NuCalm demonstrates the immune-boosting role of shifting to a parasympathetic-dominated tone.”– Tarman Aziz, MD, CCDS, CHC, Professor of Physiology and Neurology
Numerous physiological markers are available which provide data to analyze the efficacy of the NuCalm clinical system in decreasing the sympathetic nervous system response and anxiety. These markers include galvanic skin response, temperature, blood volume pulse, heart rate, heart rate variability (including HRV amp, SDNN, RMSSD, %LF, %HF, and LF/HF) and brain waves (including Beta, Alpha, Theta, and Delta amplitudes, Alpha/Theta crossover and slow cortical potentials). Each of these physiologic markers demonstrates a particular response (increase or decrease) under sympathetic and parasympathetic stimulation.
Galvanic skin response (GSR) is a method of measuring the electrical conductivity of the skin, which varies with its moisture level. This is notable because the eccrine glands are controlled by the sympathetic nervous system, so skin conductance is used as an indication of psychological or physiological arousal. There is a relationship between sympathetic activity and emotional arousal such as fear and anger. The GSR is highly sensitive to emotions in some people. Human eccrine glands receive primary signals from sympathetic cholinergic fibers that are controlled by the neurotransmitter acetylcholine. In measuring GSR, a very slight electrical current is run through the skin and changes in the salt and water in the sweat gland ducts are measured. The more emotionally aroused the subject is, the more active the sweat glands are and the greater the electrical conductivity of the skin. An increase in GSR occurs with sympathetic stimulation and decreases with parasympathetic stimulation.
Dermal temperature is another measure of sympathetic arousal. Dermal temperature decreases with sympathetic stimulation and increases with parasympathetic stimulation.
Blood volume pulse (BVP) is measured by photoplethysmography, which is a non-invasive transducer to measure the relative changes of blood volume in a subject’s finger or temple. An infrared light source is transmitted through or reflected off the tissue, detected by a phototransistor, and quantified in arbitrary units. Less light is absorbed when blood flow is greater, increasing the intensity of the light reaching the sensor. The wave form obtained from such a transducer represents the BVP of the subject, which is the phasic change in blood volume with each heartbeat. Heart rate is simply the number of beats of the heart per time interval. Heart rate increases with sympathetic stimulation and decreases with parasympathetic stimulation. The BVP likewise increases with sympathetic stimulation and decreases with parasympathetic stimulation.
Heart rate variability (HRV) consists of beat-to-beat differences in intervals between successive heartbeats. In general, emotional stress gives rise to heart rhythm patterns that appear irregular and erratic. The heart rate variability waveform under stress appears as a series of uneven, jagged peaks (i.e., an incoherent heart rhythm pattern). Physiologically, this pattern indicates that the signals produced by the two branches of the autonomic nervous system are out of sync with each other. This incoherent pattern of physiological activity associated with stressful emotions can cause the body to operate inefficiently, deplete energy, and produce extra wear- and-tear on the body. This is especially true if emotional stress is prolonged or frequent. During positive emotions, the heart rhythm pattern becomes highly ordered, appearing like a smooth, harmonious wave. This is called a coherent heart rhythm pattern. With coherent heart rhythm, the activity in the two branches of the autonomic nervous system is synchronized and the body’s systems operate with increased efficiency and harmony.
HRV data can identify anxiety and stressful influences on the cardiovascular system. The interbeat interval is a portal through which parasympathetic and sympathetic influences may be observed. HRV is a measure of the variation of the beat-to-beat interval. Increased HRV has been shown to have positive clinical significance, whereas reduced HRV has been associated with negative clinical outcomes and conditions. Variation in the beat-to-beat interval is a physiological phenomenon resulting from several different inputs to the sinoatrial node, which is the impulse-generating, pacemaker tissue located in the right atrium of the heart, and thus the generator of normal sinus rhythm. The main inputs are the sympathetic and the parasympathetic nervous systems. The two primary fluctuations are respiratory arrhythmia and low-frequency oscillations. Respiratory arrhythmia is associated with the respiratory rate and low-frequency oscillations are associated with Mayer waves of blood pressure (waves in arterial blood pressure brought about by oscillations in baroreceptor and chemoreceptor reflex control systems).
The most widely used methods for measuring HRV are time-domain methods and frequency-domain methods. The time-domain methods are based on the beat-to-beat or NN intervals, which are analyzed in a variety of ways. Included among these are the SDNN (the standard deviation of NN intervals) and the RMSSD (the square root of the mean squared difference of successive NNs). These are measures representing sympathetic or parasympathetic influence. Increased scores of these measures represent greater parasympathetic influence. Norms for these measures are: RMSSD 27.2 +/- 12.3 and SDNN 136.5 +/- 33.4.
Measurements assessed with frequency-domain methods include LF, LF norm, HF, HF norm, and LF/HF ratio. HRV rhythms in the low frequency (LF) range (between 0.04 to 0.15Hz) reflect mixed sympathetic and parasympathetic activity. Mental stress increases LF activity and is usually considered a marker of sympathetic modulation. The high frequency (HF) range (between 0.15 to 0.4Hz) contains rhythms regulated by parasympathetic activity and corresponds to N-N variations caused by respiration. Deep, even breathing activates the parasympathetic nervous system and raises the amplitude of HF. Mental stress decreases HF activity. Vagal activity is the major contributor to the HF component. With the LF/HF ratio, high numbers mean dominance of sympathetic activity while low numbers mean dominance of the parasympathetic activity. After deep and even breathing, an increase reflects changes in the parasympathetic regulation. HRV decreases with sympathetic stimulation and increases with parasympathetic stimulation. Consistent with this result, the HRV LF% and the LF/HF ratio increase with sympathetic stimulation and decrease with parasympathetic stimulation.
Various brain waves are associated with states of wakefulness and sleep, mental activity related to cognitive, sensory, and motor activities, and emotions such as fear and anxiety. Beta brain waves are the most rapid brain waves and reflect normal waking consciousness. Beta amplitudes increase with sympathetic stimulation. There is a range of Beta waves: low Beta, relaxed but alert (~13–15Hz), mid Beta, which is the learning zone (~15–19Hz), and high beta, which is the anxious brain (associated with fear and anxiety) exhibiting brain wave frequencies ~23–38Hz. Alpha waves indicate a comfortable, relaxed state, 8–12Hz, and are associated with relaxation, meditation, and idleness. Theta waves reflect a deeply relaxed state and cellular restoration, 4–7Hz. Delta waves are indicative of the sleep state wherein signals are moving through clusters of neurons very slowly, around 4Hz. Delta amplitude progressively decreases during sleep. Delta waves are related to V waves, which occur during sleep, and to slow cortical potentials.
The production of Alpha and Theta patterns in the brain is correlated to the relaxation response. The relaxation response reduces heart rate and blood pressure, relaxes muscles, and increases oxygen to the brain. The relaxation response is extremely beneficial to learning and problem solving and is accompanied by Alpha (higher amplitude, lower frequency brain waves) and theta rhythms (even greater amplitude, lower frequency brain waves). The brain wave frequencies increase with sympathetic stimulation and decrease with parasympathetic stimulation.
Alpha to Theta crossover occurs just at pre-sleep, providing a dissociative hypnagogic experience of profound relaxation. Alpha to theta crossover is where people experience restorative sleep and the loss of a sense of time and place. It is called the healing zone or psychological dissociative state. This state of consciousness is similar to a meditative or hypnotic relaxed state. The Alpha-Theta crossover state is a deeply relaxed state in the Alpha (8-12Hz) and the Theta (4-7Hz) range, right on the edge of sleep. The name comes from the behavior of the brain waves. Alpha waves are usually higher in amplitude, or more powerful, than Theta. Alpha-Theta crossover is when the amplitude of the Alpha waves drops and the Theta amplitude rises to the point where it crosses over the Alpha waves, indicating it has become more powerful. Alpha-Theta crossovers decrease with sympathetic stimulation and increase with parasympathetic stimulation.
Slow cortical potentials (SCPs) are gradual changes in the membrane potentials of cortical dendrites which are in the frequency range below 1–2Hz that last from 300ms to several seconds. Negative potential shifts indicate mobilization or higher excitability, positive SCP shifts represent reduced excitability or inhibition of neuronal activity. Slow cortical potential shifts in the electrical negative direction reflect the depolarization of large cortical cell assemblies, reducing their excitation threshold. SCPs increase with sympathetic stimulation and decrease with parasympathetic stimulation.
Imagine having the power of your brain in the palm of your hand. Since the dawn of humankind, humans have either discovered or created various ways to manage their mental state. Today, if you want more energy you can drink a coffee, a Red Bull, a Monster Energy drink, or more; if you want to feel sedated you can drink alcohol; if you want to escape your problems, you can use recreational drugs; if you don’t want to feel depressed, you can take anti-depressants; if you don’t want to feel anxious, you can take anti-anxiety drugs; or if you are having difficulty falling asleep, you can take sleeping pills. All these methods to change your mental state can be effective in the short term, but all have long-term side effects and negative consequences. But now there is a better way!
What are brain wave frequencies and how does NuCalm work with them?
The brain consists of millions of brain cells forming trillions of connections. These building blocks of the brain, called neurons, communicate with each other through chemical and electrical signals. When masses of neurons send synchronized pulses, they oscillate and produce a wave-like effect or a brain wave. Brain wave frequency is measured in Hertz (Hz) or cycles per second. Higher order brain activity will produce high-frequency brain waves, such as beta or gamma waves. When we are awake, talking and in a normal working consciousness, we are in the beta brain wave frequency. As shown in the chart, human brain waves oscillate in a frequency range of 0.5Hz – 41Hz, and include 5 categories (delta > theta > alpha > beta > gamma).
Many people spend too much time in higher frequencies associated with stress, fear, anxiety, and worry. This frequency range elicits the stress hormone, cortisol along with adrenaline and makes it difficult to down regulate the stress response, called the sympathetic nervous system. On the other side of the stress response is the rest and digest response, called the parasympathetic nervous system. This aspect of the autonomic nervous system is critical for balance, good health, and wellbeing, lowering inflammation, improving immune strength, and increasing resilience. The challenge for people is how to stop the stress response reliably and safely.
NuCalm’s patented technology uses complex physics, mathematics, and algorithms built into a software that lies beneath music. This neuroacoustic software presents the brain with a signal via the auditory motor cortex, and the brain follows the signal. The key NuCalm channels for activating the parasympathetic nervous system are Rescue, PowerNap, and FlowState. These channels slow down brain waves into Alpha and then hold them in an oscillating pattern of Theta (4Hz – 7Hz). Theta is known as the healing zone because when your brain is in theta, the cells do their maintenance and clean toxins out of the cells, and the mitochondria (cell’s energy source) is restored. Theta activity is associated with light REM sleep, dreaming, meditation, deep restoration, and the replenishment of hormone reservoirs. Alpha activity is associated with relaxation, greater awareness, and the production of serotonin, a mood balancing hormone. The Alpha-Theta crossover state is a combination of both Alpha and Theta brain wave frequencies, where you experience hypnogogic dissociation (loss of time and space), and all the therapeutic benefits of cellular restoration can take place. Rescue, PowerNap, and FlowState predictably guide brain wave frequencies to the healing zone every time you use them.
During a Rescue, PowerNap, or FlowState journey, the brain will dip into Delta, especially if the person is sleep deprived, but NuCalm’s main goal is to get the person into a state right above deep sleep. This is the optimal recovery zone of the mind and body, and spending enough time in this state every day is essential to our health. This is the state where the parasympathetic nervous system replenishes our body’s resources that were depleted from stress, fear, anxiety, and worry, which causes sympathetic overload. Typically, people describe their Rescue, PowerNap, or FlowState journey as being aware of their surroundings while simultaneously feeling like they are in a deep sleep with slowed breathing, lower heart rate, a heaviness to the body, a wandering mind, but no bodily movement.
Because NuCalm slows your brain waves, so fast and so reliably, your body is able to receive many of the benefits of restorative sleep without actually being asleep. According to research at Harvard Medical School, you get over 2 hours of restorative sleep in just 20 minutes with NuCalm.
The autonomic nervous system (ANS) controls the involuntary bodily functions – pupillary response, heart rate, respiration, digestion, and sexual arousal. The autonomic nervous system is composed of the sympathetic nervous system (stress response) and the parasympathetic nervous system (rest and digest response). The ANS manages human stress, fear, anxiety, depression, and worry, in addition to the fight-or-flight-or-freeze response. In humanity’s ancient past, the fight-or-flight response played an essential role in helping to keep our ancestors alive in the face of such dangers as predatory animals and natural occurrences such as earthquakes, floods, and volcanic eruptions. Researchers have discovered that actual physical danger is not necessary to trigger the fight-or-flight response. It can also be triggered by our thoughts and beliefs. Simply put, if you habitually focus on thoughts and beliefs of a limiting or negative nature, you are causing your body to act as if it is in danger. This results in the chronic production of stress hormones, specifically cortisol.
The biochemical signaling of the NuCalm clinical system includes a proprietary blend of inhibitory neurotransmitters, primarily GABA (Gamma-Aminobutyric Acid). GABA is the main inhibitory neurotransmitter in the central nervous system. GABAergic inhibition is seen at all levels of the CNS, including the hypothalamus, hippocampus, cerebral cortex, and cerebellar cortex. In addition to the large well established GABA pathways, GABA interneurons are abundant in the brain, with 50% of the inhibitory synapses in the brain being GABA mediated. In individuals with anxiety spectrum disorders or autonomic nervous system dysfunction these pathways are not optimally biologically functional. Anxiolytics will bind to the GABA receptors but do nothing to return the pathways to optimal function.
The NuCalm biosignal processing discs deliver the frequencies of GABA directly to the brain using resonance and biomodulation, like a tuning fork. This delivery mechanism overrides the body’s metabolic and absorption processes, including the challenge of penetrating the blood brain barrier. Every chemical has a signature frequency. Dr. Holloway worked with scientists in Germany and China for more than 4 years to identify the exact frequencies of the seven inhibitory neurotransmitters that were in the NuCalm transdermal cream. Once the specific frequencies were determined, it took over a year of trial and error and alchemy to adjust the frequency imprints to mimic the exact molecular formulation of the NuCalm transdermal cream. The NuCalm biosignal processing discs are then created by imprinting a signature frequency recipe inside a Tesla coil onto a six-layer Lakhovksy Multiwave Oscillator. The discs are protected from EMFs by being packaged in a Faraday bag.
Traditional Chinese Medicine explains that Qi (light energy) flows through the body along particular pathways, or Meridians, to maintain health. Everything in the world as we know it vibrates with a particular pattern, thus living systems produce electromagnetic frequencies endogenously that differ depending on the level of health or disease. It is hypothesized that if you can restore the frequencies that travel through the Meridians you can reinstate optimal physiology. Each NuCalm disc holds the electromagnetic frequency patterns of GABA and its precursors to deliver a pure biological signal to your body. When placed on the inside of your left wrist, at your Pericardium-6 acupuncture point, the disc sends a signal to the pericardium of your heart to activate local parasympathetic nerve fibers, which then transmit the signal to your brain telling it to increase vagal nerve output and begin the process of slowing down the body. The disc stops your acute stress response, so the brainwave entrainment with NuCalm’s patented neuroacoustic software is always reliable, fast acting, and efficient at getting you into Theta brain wave range, where cellular restoration and relaxation can take place.
A properly functioning GABAergic system is vital for relaxation, cellular restoration, and balance. NuCalm Rescue, PowerNap, and FlowState help reduce stress, promote recovery and generate calm by working at the root causes of the problem – the imbalanced neurochemical and neuroelectrical systems of the autonomic nervous system.
The brain’s chemical messengers or neurotransmitters are either excitatory, inhibitory or modulatory. The main excitatory neurotransmitter is glutamate, and its role is to potentiate signals forward and increase neuronal activity. The major inhibitory neurotransmitter, GABA, inhibits nerve activity by preventing signals from moving forward, thus calming the brain. It does this by interrupting the HPA and downregulating the secretion of adrenaline. The common neuromodulatory neurotransmitters are either serotonin or dopamine. Serotonin plays numerous important roles within the brain including regulating your mood, increasing your learning and memory, and is a chemical precursor for melatonin, an important sleep hormone. Dopamine is most well-known as the reward or pleasure chemical. Many studies have associated various neurological disorders with either the excess or deficit of a specific neurotransmitter. For example, increased dopamine levels have been found in people with addiction disorders, whereas decreased serotonin levels have been theorized to contribute to depression. Chronic stress is related to an improperly functioning GABAergic system that can no longer control the over-excitation and hyperactivity in the brain. Balance in neurochemical levels is the key to optimal brain health and function.
U.S. Patent Registration No.: 9,079,030: Systems and methods for maintaining and balancing the health of the human autonomic nervous system.
U.S. Patent Registration No.: 11,090,459: Methods and devices for applying dynamic, non-linear oscillations and vibrations to elicit a physiological state change in humans.
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The Patented 
Biosignal Processing Disc
Your body is an electrical conduit filled with conductive saline. Our Patented Biosignal Processing Discs create an electical feedback loop directly to your brain, using frequency resonance to calm your autonomic nervous system and prime your body and mind for recovery.
Our Biosignal Processing Discs contain ZERO drugs. The design you see on the outside houses small bits of copper that hold an very light electrical charge.
When Applied to the Pericardium 6 accupressure point, the charge in the disc is activated by your body’s Gauss Field, the natural electromagnetic field that surrounds every human. Once activated, the disc produces a frequency that instructs your brain to begin creating the Neurotransmitter GABA.
Absolutely 100% Safe for pets, children, plants, or any living thing. The minute charge in the discs cannot shock you. GABA is already present in your body, and is safe at any level, its primary purpose is to supress your autonomic nervous system (stress response) and help you begin to relax.
To learn the complete science behind our patented Biosignal Processing Discs Click Here
